The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Cancer metastasis is the leading cause of mortality in patients with cancer. Theories have
been developed to explain the causes and principles of metastasis. Metastasis is attributed …

The intersection of the microbiota and cancer and the mechanisms that define these
interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here …

The symbiotic bacteria that live in the human gut and the metabolites they produce have
long influenced local and systemic physiological and pathological processes of the host …

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which
increases the risk of renal failure and causes a high global disease burden. Due to the lack …

Accumulating evidence indicates that gut microbiota closely correlates with the
tumorigenesis of digestive system cancers (DSCs). However, whether the causality between …

The immune checkpoint blockade (ICB) response in human cancers is closely linked to the
gut microbiota. Here, we report that the abundance of commensal Lactobacillus johnsonii is …

Natural killer (NK) cells, as key immune cells, play essential roles in tumor cell immune
escape and immunotherapy. Accumulating evidence has demonstrated that the gut …

The past decade has witnessed a revolution in cancer treatment by shifting from
conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies …

Cancer is a multi-step process that can be viewed as a cellular and immunological shift
away from homeostasis in response to selected infectious agents, mutations, diet, and …