The complex link between NAFLD and type 2 diabetes mellitus—mechanisms and treatments

G Targher, KE Corey, CD Byrne… - … reviews Gastroenterology & …, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide.
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease

AS Abdelhamid, TJ Brown, JS Brainard… - Cochrane Database …, 2018 - cochranelibrary.com
Background Researchers have suggested that omega‐3 polyunsaturated fatty acids from
oily fish (long‐chain omega‐3 (LCn3), including eicosapentaenoic acid (EPA) and …

Update on NAFLD genetics: from new variants to the clinic

E Trépo, L Valenti - Journal of hepatology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled …

JW Eriksson, P Lundkvist, PA Jansson, L Johansson… - Diabetologia, 2018 - Springer
Abstract Aims/hypothesis The EFFECT-II study aimed to investigate the effects of
dapagliflozin and omega-3 (n-3) carboxylic acids (OM-3CA), individually or combined, on …

[HTML][HTML] KASL clinical practice guidelines: management of nonalcoholic fatty liver disease

SH Kang, HW Lee, JJ Yoo, Y Cho, SU Kim… - Clinical and …, 2021 - ncbi.nlm.nih.gov
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide
as the obese and diabetic populations increase, and it has been estimated to be 20–30% in …

Retracted: M2 Macrophage–Derived Exosomes Facilitate HCC Metastasis by Transferring αMβ2 Integrin to Tumor Cells

J Wu, W Gao, Q Tang, Y Yu, W You, Z Wu, Y Fan… - …, 2021 - Wiley Online Library
Background and Aims The development and progression of hepatocellular carcinoma
(HCC) is dependent on its local microenvironment. Tumor‐associated macrophages (TAMs) …

Bioactive lipid species and metabolic pathways in progression and resolution of nonalcoholic steatohepatitis

G Musso, M Cassader, E Paschetta, R Gambino - Gastroenterology, 2018 - Elsevier
The prevalence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, yet there
are no effective treatments. A decade has passed since the initial lipidomics analyses of liver …

Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

G Targher, CD Byrne - Nature Reviews Nephrology, 2017 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is caused by an accumulation of fat in the liver; the
condition can progress over time to increase the risk of developing cirrhosis, end-stage liver …

[HTML][HTML] Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease

AS Abdelhamid, N Martin, C Bridges… - … of systematic reviews, 2018 - ncbi.nlm.nih.gov
Background Evidence on the health effects of total polyunsaturated fatty acids (PUFA) is
equivocal. Fish oils are rich in omega‐3 PUFA and plant oils in omega‐6 PUFA. Evidence …

Leveraging human genetics to identify potential new treatments for fatty liver disease

S Romeo, A Sanyal, L Valenti - Cell metabolism, 2020 - cell.com
Fatty liver disease (FLD), including its more severe pathologies, namely steatohepatitis,
hepatocarcinoma, and cirrhosis, is the most common cause of chronic liver disease …