[HTML][HTML] Alkaloids used as medicines: Structural phytochemistry meets biodiversity—An update and forward look

M Heinrich, J Mah, V Amirkia - Molecules, 2021 - mdpi.com
Selecting candidates for drug developments using computational design and empirical rules
has resulted in a broad discussion about their success. In a previous study, we had shown …

The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels

C Chen, S Nakagawa, Y An, K Ito, Y Kitaichi… - Frontiers in …, 2017 - Elsevier
Exercise is known to have beneficial effects on cognition, mood, and the brain. However,
exercise also activates the hypothalamic–pituitary–adrenal axis and increases levels of the …

Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids

AL Harvey, LC Young, AM Viljoen… - Journal of …, 2011 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The South African plant Sceletium tortuosum
has been known for centuries for a variety of traditional uses, and, more recently, as a …

[HTML][HTML] Pharmacology of herbal sexual enhancers: a review of psychiatric and neurological adverse effects

P Brunetti, AF Lo Faro, A Tini, FP Busardò, J Carlier - Pharmaceuticals, 2020 - mdpi.com
Sexual enhancers increase sexual potency, sexual pleasure, or libido. Substances
increasing libido alter the concentrations of specific neurotransmitters or sex hormones in …

[HTML][HTML] Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus

D Terburg, S Syal, LA Rosenberger, S Heany… - …, 2013 - nature.com
Abstract The South African endemic plant Sceletium tortuosum has a long history of
traditional use as a masticatory and medicine by San and Khoikhoi people and …

High-mesembrine Sceletium extract (Trimesemine™) is a monoamine releasing agent, rather than only a selective serotonin reuptake inhibitor

DD Coetzee, V López, C Smith - Journal of ethnopharmacology, 2016 - Elsevier
Ethnopharmacological relevance Extracts from and alkaloids contained in plants in the
genus Sceletium have been reported to inhibit ligand binding to serotonin transporter. From …

Mesembryanthemum tortuosum L. alkaloids modify anxiety-like behaviour in a zebrafish model

VB Maphanga, K Skalicka-Wozniak… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Mesembryanthemum tortuosum L.(previously known as
Sceletium tortuosum (L.) NE Br.) is indigenous to South Africa and traditionally used to …

[HTML][HTML] A Chewable Cure “Kanna”: Biological and Pharmaceutical Properties of Sceletium tortuosum

MC Manganyi, CC Bezuidenhout, T Regnier, CN Ateba - Molecules, 2021 - mdpi.com
Sceletium tortuosum (L.) NE Br.(Mesembryanthemaceae), commonly known as kanna or
kougoed, is an effective indigenous medicinal plant in South Africa, specifically to the native …

[HTML][HTML] Sceletium for managing anxiety, depression and cognitive impairment: a traditional herbal medicine in modern-day regulatory systems

T Brendler, JA Brinckmann, U Feiter… - Current …, 2021 - ncbi.nlm.nih.gov
Modern-day regulatory systems governing conditions for how health products enter national
markets constitute a barrier of access for traditional herbal medicines on an international …

Screening selected medicinal plants for potential anxiolytic activity using an in vivo zebrafish model

VB Maphanga, K Skalicka-Woźniak, B Budzynska… - …, 2020 - Springer
Rationale Medicinal plants are used extensively in many countries to treat conditions related
to the central nervous system (CNS), and there is renewed interest to explore natural …