Converting genetic information into functional proteins is a complex, multi-step process, with
each step being tightly regulated to ensure the accuracy of translation, which is critical to …

In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA)
nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the …

Eukaryotic elongation factor 1A (eEF1A) canonically delivers amino acyl tRNA to the
ribosomal A site during the elongation stage of protein biosynthesis. Yet paradoxically, the …

Ribosomes frequently stall during mRNA translation, resulting in the context-dependent
activation of quality control pathways to maintain proteostasis. However, surveillance …

Translation termination is an essential cellular process, which is also of therapeutic interest
for diseases that manifest from premature stop codons. In eukaryotes, translation termination …

Single-molecule FRET (smFRET) has become a versatile tool for probing the structure and
functional dynamics of biomolecular systems, and is extensively used to address questions …

Suppression of premature termination codons (PTCs) by translational readthrough is a
promising strategy to treat a wide variety of severe genetic diseases caused by nonsense …

Skeletal muscle mass plays a pivotal role in metabolic function, but conditions such as bed
rest or injury often render resistance training impractical. The beta2‐adrenergic receptor has …

Didemnins are a class of cyclic depsipeptides derived from sea tunicates that exhibit potent
anticancer, antiviral, and immunosuppressive properties. Although certain Tistrella species …

Eukaryotic elongation factors (eEFs) are protein factors that mediate the extension of peptide
chain, among which eukaryotic elongation factor 1 alpha (eEF1A) is one of the most …