Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine

Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in
intracellular communication through EV-encapsulated informative content, including …

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Q Si, L Wu, D Pang, P Jiang - MedComm, 2023 - Wiley Online Library
Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally
secreted by cells into body fluids. They are derived from endosomes and are wrapped in …

Cerebral endothelial cell-derived extracellular vesicles regulate microglial polarization and promote autophagy via delivery of miR-672-5p

C Wang, L Feng, L Zhu, L Wu, B Chen, C Cui… - Cell death & …, 2023 - nature.com
The interaction between cerebral endothelial cells (CEC) and brain parenchymal cells is
critical to maintain neurovascular homeostasis, whereas extracellular vesicles (EVs) are …

[HTML][HTML] Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an …

H Liu, M Jin, M Ji, W Zhang, A Liu, T Wang - Aging (albany NY), 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common dementia in the world. Increasing evidence
has shown that exosomes from hypoxic pretreated adipose-derived stem cells (ADSCs) …

Extracellular vesicles: emerging roles in developing therapeutic approach and delivery tool of Chinese herbal medicine for the treatment of depressive disorder

Q Wu, WZ Duan, JB Chen, XP Zhao, XJ Li… - Frontiers in …, 2022 - frontiersin.org
Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells, which play
an essential role in intercellular communication by delivering cellular components including …

The important roles of microRNAs in depression: new research progress and future prospects

C Miao, J Chang - Journal of Molecular Medicine, 2021 - Springer
MicroRNAs (miRNAs) are non-encoding, single-stranded RNA molecules of about 22
nucleotides in length encoded by endogenous genes involved in posttranscriptional gene …

Effects of exosomes on adult hippocampal neurogenesis and neuropsychiatric disorders

Y Zhang, C Xu - Molecular biology reports, 2022 - Springer
Exosomes are extracellular vesicles originating from the endosomal system, which are
involved in intercellular substance transfer and cell waste elimination. Recent studies …

[HTML][HTML] Plant-derived nanovesicles: Promising therapeutics and drug delivery nanoplatforms for brain disorders

R Wang, Y Zhang, Y Guo, W Zeng, J Li, J Wu, N Li… - Fundamental …, 2023 - Elsevier
Abstract Plant-derived nanovesicles (PDNVs), including plant extracellular vesicles (EVs)
and plant exosome-like nanovesicles (ELNs), are natural nano-sized membranous vesicles …

HDAC8-inhibitor PCI-34051-induced exosomes inhibit human bronchial smooth muscle cell proliferation via miR-381-3p mediated TGFB3

SY Bai, ML Li, Y Ren, XM Su - Pulmonary Pharmacology & Therapeutics, 2021 - Elsevier
The present study aimed to investigate the effects of PCI-34051-induced human bronchial
epithelial cells (HBECs)-derived exosomes (PCI-Exo) on human bronchial smooth muscle …

Extracellular Vesicles from Neural Stem Cells Carry microRNA-16-5p to Reduce Corticosterone-induced Neuronal Injury in Depression Rats

X Min, H Liu, X Dou, F Chen, Q Zhao, X Zhao, Y Shi… - Neuroscience, 2024 - Elsevier
Objective Depression is a common mental illness. Neural stem cell-derived extracellular
vesicles (NSC-EVs) are involved in repairing neuronal injury. We estimated the mechanism …