The pathogenesis of dengue virus infection is attributed to complex interplay between virus,
host genes and host immune response. Host factors such as antibody-dependent …

Mortality from severe dengue is low, but the economic and resource burden on health
services remains substantial in endemic settings. Unfortunately, progress towards …

Dengue is caused by the dengue virus (DENVs) infection and clinical manifestations include
dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS) …

Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

Since its initial isolation in Uganda in 1937 through the present, West Nile virus (WNV) has
become an important cause of human and animal disease worldwide. WNV, an enveloped …

West Nile virus (WNV) is an important zoonotic flavivirus responsible for mild fever to severe,
lethal neuroinvasive disease in humans, horses, birds, and other wildlife species. Since its …

Flaviviruses cause systemic or neurotropic-encephalitic pathology in humans. The flavivirus
nonstructural protein 1 (NS1) is a secreted glycoprotein involved in viral replication, immune …

Arthropod-borne viruses (arboviruses) circulate in nature between arthropod vectors and
vertebrate hosts. Arboviruses often cause devastating diseases in vertebrate hosts, but they …

Flaviviruses are emerging arthropod-borne viruses representing an immense global health
problem. The prominent viruses of this group include dengue virus, yellow fever virus …

The flavivirus nonstructural glycoprotein NS1 is an enigmatic protein whose structure and
mechanistic function have remained somewhat elusive ever since it was first reported in …