In this Review, I present evidence supporting a multifactorial causation of childhood acute
lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two …

Objective Advanced parental age has raised additional concern as a risk factor of autism.
We conducted a meta‐analysis of observational studies investigating the association …

BACKGROUND Maternal factors, including increasing childbearing age and various life-
style factors, are associated with poorer short-and long-term outcomes for children, whereas …

Simple Summary Acute leukemias are some of the most common cancers affecting all age
groups. Despite a significant improvement made in the treatment of acute leukemias, their …

Although overall incidence is rare, leukemia is the most common type of childhood cancer. It
accounts for 30% of all cancers diagnosed in children younger than 15 years. Within this …

The majority of childhood leukemias are precursor B-cell acute lymphoblastic leukemias (pB-
ALLs) caused by a combination of prenatal genetic predispositions and oncogenic events …

Childhood leukaemia is the principal subtype of paediatric cancer and, despite success in
treatment, its causes remain enigmatic. A plethora of candidate environmental exposures …

Identical infant twins with concordant leukemia were first described in 1882, and since that
time many such pairs of infants and older children have been described. It has long been …

The causes of childhood cancer have been systematically studied for several decades, but
apart from high-dose radiation and prior chemotherapy there are few or no strong external …

Objective To explore the association between maternal and paternal age and risk of autism
spectrum disorders (ASDs) in offspring. Design Historical birth cohort study. Setting Kaiser …