The development of novel therapeutic approaches is necessary to manage gastrointestinal
cancers (GICs). Considering the effective molecular mechanisms involved in tumor growth …

Downregulated expression of anti-tumor miR-383 has been found in many kinds of cancer.
MiR-383 family members can directly target the 3′-untranslated region (3′-UTR) of the …

Abstract Background Cancer-associated fibroblasts (CAFs) contribute notably to colorectal
cancer (CRC) tumorigenesis, stiffness, angiogenesis, immunosuppression and metastasis …

Abstract Treatment resistance is one of the major barriers for therapeutic strategies in
hepatocellular carcinoma (HCC). Many studies have indicated that chemotherapy and …

Background Hepatocellular carcinoma (HCC) remains one of the most common malignant
neoplasms. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) plays a key role in the …

Gastric cancer (GC) is a tumor with high incidence and lack of early diagnostic markers. The
aim of this study was to explore novel regulatory circular RNAs (circRNAs) in GC and their …

Because of their increasing prevalence, gastrointestinal (GI) cancers are regarded as an
important global health challenge. Microorganisms residing in the human GI tract, termed …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Autophagy is known as a conserved self-eating mechanism that contributes to cells to
degrade different intracellular components (ie, macromolecular complexes, aggregated …

Gastric cancer (GC) development is a complex process displaying polytropic cell and
molecular landscape within gastric tumor microenvironment (TME). Stromal cells in TME …