Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive
deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is …

Huntington disease (HD) is a debilitating, currently incurable disease. Protein aggregation
and metabolic deficits are pathological hallmarks but their link to neurodegeneration and …

Hair is a noninvasive valuable biospecimen for the long-term assessment of endogenous
metabolic disturbance. Whether the hair is suitable for identifying biomarkers of the …

Last data demonstrated that exonic variants of LRRK2 (p. G2019S, p. M1646T) may affect
the catalytic activity of lysosomal enzyme glucocerebrosidase (GCase) probably through the …

Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is a sleep disorder that
is characterised by dream enactment episodes during REM sleep. It is the strongest known …

The identification of Parkinson's disease (PD) biomarkers has become a main goal for the
diagnosis of this neurodegenerative disorder. PD has not only been intrinsically related to …

Abstract Background Sphingolipid dysregulation in Parkinson's disease (PD) may affect the
release and uptake of striatal dopamine. However, the longitudinal relationship between …

Abstract α-Synuclein, a protein mostly present in presynaptic terminals, accumulates
neuropathologically in Parkinson's disease in a 6-stage sequence and propagates in the …

Background Sphingolipids are implicated in neurodegeneration and neuroinflammation. We
assessed the potential role of circulating ceramides and sphingomyelins in subclinical brain …

In China, Parkinson's disease (PD) is the second most prevalent central nervous system
(CNS) degenerative illness affecting middle-aged and older persons. Movement disorders …