Peptide-based supramolecular systems chemistry seeks to mimic the ability of life forms to
use conserved sets of building blocks and chemical reactions to achieve a bewildering array …

Peptides are small yet versatile building blocks of biomaterials. This Comment highlights
recent progress in the design of liquid-like microdroplets, or coacervates, based on peptides …

Bottom‐up synthetic biology is the science of building systems that mimic the structure and
function of living cells from scratch. To do this, researchers combine tools from chemistry …

Conspectus Coacervates are droplets formed by liquid–liquid phase separation (LLPS) and
are often used as model protocells–primitive cell-like compartments that could have aided …

Peptide self-assembly provides an innovative strategy for not only establishing an ideal
research model to understand life phenomena but also for constructing sophisticated …

The origin of life is still one of humankind's great mysteries. At the transition between
nonliving and living matter, protocells, initially featureless aggregates of abiotic matter, gain …

Liquid–liquid phase separation of disordered proteins has emerged as a ubiquitous route to
membraneless compartments in living cells, and similar coacervates may have played a role …

Liquid-liquid phase separation yields spherical droplets that eventually coarsen to one
large, stable droplet governed by the principle of minimal free energy. In chemically fueled …

Conspectus Cells have evolved to be self-sustaining compartmentalized systems that
consist of many thousands of biomolecules and metabolites interacting in complex cycles …

The design of compartmentalized colloids that exhibit biomimetic properties is providing
model systems for developing synthetic cell-like entities (protocells). Inspired by the cell …