The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The function of biomolecular condensates is often restricted by condensate dissolution.
Whether condensates can be suppressed without condensate dissolution is unclear. Here …

Finding the components of cellular circuits and determining their functions systematically
remains a major challenge in mammalian cells. Here, we introduced genome-wide pooled …

Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for
the identification of protein-protein interactions. However, for any given protein of interest …

The Hippo pathway regulates organ size and tissue homeostasis in response to multiple
stimuli, including cell density and mechanotransduction. Pharmacological inhibition of …

Hair cells of the inner ear are essential for hearing and balance. As a consequence,
pathogenic variants in genes specifically expressed in hair cells often cause hereditary …

Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have
been associated with defects in the organization of endothelial cell junctions. Understanding …

Identifying the interactions established by a protein of interest can be a critical step in
understanding its function. This is especially true when an unknown protein of interest is …

Signalling networks regulate essentially all of the biology of cells and organisms in normal
and disease states. Signalling is often studied using antibody-based techniques such as …