This review focuses on the application of hypothermic perfusion technology as a topic of
current interest with the potential to have a salutary impact on the mounting clinical …

The introduction of insulin therapy for the management of diabetes mellitus is arguably the
greatest milestone in the history of modern medicine. β‐cell replacement therapy is the only …

This study investigated the recovery of pancreatic insulin content during human islet
isolation prior to and after digestion-filtration, continuous Hanks-Ficoll gradient purification …

Islet allotransplantation can achieve insulin independence in patients with type I diabetes.
Recent reports show that the two-layer method (TLM), which employs oxygenated …

One of the most significant problems hindering clinical pancreatic islet transplantation
worldwide is the variabilн ity of the collagenase digestion phase of human islet isolation …

Different factors have been reported to influence islet isolation outcome, but their importance
varies between studies and are hampered by the small sample sizes in most studies. The …

Ischemic injury of the human cadaver donor pancreas during cold storage is conceivably the
single most ignored impediment to successful islet cell transplantation. Protecting pancreatic …

Islet transplantation is a useful therapeutic choice for severe diabetes mellitus; however,
limited donor supplies have interfered with the use of this treatment. Therefore, the …

For islet transplantation, it is important to obtain an available islet mass adequate for
diabetes reversal from a single donor pancreas. A recent report demonstrated that the use of …

University of Wisconsin (UW) solution is used extensively as a cold storage solution during
the procurement and transport of the pancreas prior to islet isolation. However, it has been …