[PDF][PDF] Molecular evolution of hemagglutinin gene of Influenza A virus

A De - Front. Biosci, 2018 - researchgate.net
In the history of human civilization, influenza is the second most catastrophic killer disease
for mankind with plague ranking first in the medieval times. The 1918–1919 'Spanish …

Dominant clade‐featured SARS‐CoV‐2 co‐occurring mutations reveal plausible epistasis: An in silico based hypothetical model

ASMRU Alam, OK Islam, MS Hasan… - Journal of medical …, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has evolved into eight
fundamental clades with four of these clades (G, GH, GR, and GV) globally prevalent in …

[HTML][HTML] Evolutionary Insights from Association Rule Mining of Co-Occurring Mutations in Influenza Hemagglutinin and Neuraminidase

V Galeone, C Lee, MT Monaghan, DC Bauer… - Viruses, 2024 - mdpi.com
Seasonal influenza viruses continuously evolve via antigenic drift. This leads to recurring
epidemics, globally significant mortality rates, and the need for annually updated vaccines …

Tracking of Mutational Signature of SARS-CoV-2 Omicron on Distinct Continents and Little Difference was Found

SY Zheng, YP Zhang, YX Liu, W Zhao, XL Peng… - Viruses, 2023 - mdpi.com
The Omicron variant is currently ravaging the world, raising serious concern globally.
Monitoring genomic variations and determining their influence on biological features are …

A phase 1 randomized placebo-controlled study to assess the safety, immunogenicity and genetic stability of a new potential pandemic H7N9 live attenuated influenza …

I Kiseleva, I Isakova-Sivak, M Stukova, M Erofeeva… - Vaccines, 2020 - mdpi.com
This study describes a double-blind randomized placebo-controlled phase I clinical trial in
healthy adults of a new potential pandemic H7N9 live attenuated influenza vaccine (LAIV) …

Evolving infection paradox of SARS-CoV-2: fitness costs virulence?

ASMRU Alam, OK Islam, MS Hasan, MR Islam… - MedRxiv, 2021 - medrxiv.org
Background SARS-CoV-2 is continuously spreading worldwide at an unprecedented scale
and evolved into seven clades according to GISAID where four (G, GH, GR and GV) are …

Mass-based protein phylogenetic approach to identify epistasis

KM Downard - Epistasis: Methods and protocols, 2021 - Springer
A mass-based protein phylogeny method, known as phylonumerics, is described to build
phylogenetic-like trees using a purpose-built MassTree algorithm. These trees are …

Identification of potential critical virulent sites based on hemagglutinin of influenza a virus in past pandemic strains

R Yin, X Zhou, FX Ivan, J Zheng, VTK Chow… - Proceedings of the 6th …, 2017 - dl.acm.org
The influenza pandemics have caused millions of deaths and enormous economic loss.
Current circulating influenza viruses in human, avian, swine and other animals are potential …

Nucleotide-based genetic networks: Methods and applications

RK Verma, P Shinde, S Jalan - Journal of Biosciences, 2022 - Springer
Genomic variations have been acclaimed as among the key players in understanding the
biological mechanisms behind migration, evolution, and adaptation to extreme conditions …

Structural significance of residues 158–160 in the H3N2 hemagglutnin globular head: A computational study with implications in viral evolution and infection

ME Cueno, H Shiotsu, K Nakano, E Sugiyama… - Journal of Molecular …, 2019 - Elsevier
Abstract Influenza A H3N2 has been linked to annual outbreaks within the human
population attributable to continuous structural changes. H3N2 HA contains well identified …