DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
The continuum of aging and age-related diseases: common mechanisms but different rates
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …
there is considerable between-person variation in the rate of ageing and individual …
Measuring aging and identifying aging phenotypes in cancer survivors
JL Guida, TA Ahles, D Belsky, J Campisi… - JNCI: Journal of the …, 2019 - academic.oup.com
Observational data have shown that some cancer survivors develop chronic conditions like
frailty, sarcopenia, cardiac dysfunction, and mild cognitive impairment earlier and/or at a …
frailty, sarcopenia, cardiac dysfunction, and mild cognitive impairment earlier and/or at a …
Methylation-based biological age and breast cancer risk
Background Age is one of the strongest predictors of cancer, chronic disease, and mortality,
but biological responses to aging differ among people. Epigenetic DNA modifications have …
but biological responses to aging differ among people. Epigenetic DNA modifications have …
Epigenetic aging: more than just a clock when it comes to cancer
M Yu, WD Hazelton, GE Luebeck, WM Grady - Cancer research, 2020 - AACR
The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …
[HTML][HTML] DNA methylation dynamics in aging: how far are we from understanding the mechanisms?
F Ciccarone, S Tagliatesta, P Caiafa… - Mechanisms of ageing …, 2018 - Elsevier
DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …
predicting life expectancy. However, the mechanisms underlying age-related DNA …
Prospective study of epigenetic age acceleration and incidence of cardiovascular disease outcomes in the ARIC study (Atherosclerosis Risk in Communities)
NS Roetker, JS Pankow, J Bressler… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: DNA methylation-based patterns of biological aging, known as epigenetic age
acceleration, are predictive of all-cause mortality, but little is known about their association …
acceleration, are predictive of all-cause mortality, but little is known about their association …
Cancer treatment-induced accelerated aging in cancer survivors: biology and assessment
Simple Summary Many modalities used to treat or control cancer lead to accelerated aging
in cancer survivors. However, the effects of cancer treatments on aging in individuals with …
in cancer survivors. However, the effects of cancer treatments on aging in individuals with …