Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from
lysophosphatidyl choline (LPC), and it is up-regulated in many inflammatory conditions …

Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids including
blood. ATX catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic …

Rheumatoid arthritis is a destructive arthropathy characterized by chronic synovial
inflammation that imposes a substantial socioeconomic burden. Under the influence of the …

Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate
from lysophosphatidylcholine, the most abundant phospholipid in blood plasma …

Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family
of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses …

Rheumatoid arthritis (RA) is a chronic inflammatory syndrome designated by synovial joint
inflammation leading to cartilage degradation and bone damage as well as progressive …

Introduction Chemerin is a chemotactic agonist identified as a ligand for ChemR23 that is
expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the …

Background Microglia, the immunocompetent cells of the CNS, rapidly respond to brain
injury and disease by altering their morphology and phenotype to adopt an activated state …