The pH of the tumor microenvironment drives the metastatic phenotype and
chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH …

Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …

Alterations in tumour metabolism and acid/base regulation result in the formation of a hostile
environment, which fosters tumour growth and metastasis. Acid/base homoeostasis in …

Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by
cancer cells from many tumor types, and is a component of the pH regulatory system …

An acidic extracellular pH is a fundamental property of the malignant phenotype. In von
Hippel-Lindau (VHL)-defective tumors the cell surface transmembrane carbonic anhydrase …

Introduction Several isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …

The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …

Purpose: Metastatic renal cell carcinoma (RCC) has a poor prognosis and an unpredictable
course. To date, there are no molecular markers which can reliably predict RCC outcome …

The acidic tumour microenvironment is now recognized as a tumour phenotype that drives
cancer somatic evolution and disease progression, causing cancer cells to become more …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …