[HTML][HTML] A role for microfluidic systems in precision medicine

JM Ayuso, M Virumbrales-Muñoz, JM Lang… - Nature …, 2022 - nature.com
Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

[HTML][HTML] A review of circulating tumour cell enrichment technologies

AJ Rushton, G Nteliopoulos, JA Shaw, RC Coombes - Cancers, 2021 - mdpi.com
Simple Summary Circulating tumour cells (CTCs) are cancer cells shed into the bloodstream
from tumours and their analysis can provide important insights into cancer detection and …

A conduit to metastasis: circulating tumor cell biology

DS Micalizzi, S Maheswaran… - Genes & …, 2017 - genesdev.cshlp.org
Advances in the enrichment and analysis of rare cells from the bloodstream have allowed for
detection and characterization of circulating tumor cells (CTCs) from patients with cancer …

Fundamentals and applications of inertial microfluidics: A review

J Zhang, S Yan, D Yuan, G Alici, NT Nguyen… - Lab on a Chip, 2016 - pubs.rsc.org
In the last decade, inertial microfluidics has attracted significant attention and a wide variety
of channel designs that focus, concentrate and separate particles and fluids have been …

[HTML][HTML] Circulating tumor cell technologies

MM Ferreira, VC Ramani, SS Jeffrey - Molecular oncology, 2016 - Elsevier
Circulating tumor cells, a component of the “liquid biopsy”, hold great potential to transform
the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of …

Cancer diagnosis: from tumor to liquid biopsy and beyond

R Vaidyanathan, RH Soon, P Zhang, K Jiang, CT Lim - Lab on a Chip, 2019 - pubs.rsc.org
Technological advancements in research on circulating biomarkers from patient derived
blood have enabled a less invasive means of diagnosing non-hematologic cancers …

Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics

ME Warkiani, BL Khoo, L Wu, AKP Tay, AAS Bhagat… - Nature protocols, 2016 - nature.com
Circulating tumor cells (CTCs) are rare cancer cells that are shed from primary or metastatic
tumors into the peripheral blood circulation. Phenotypic and genetic characterization of …

Challenges in circulating tumour cell research

C Alix-Panabières, K Pantel - Nature Reviews Cancer, 2014 - nature.com
During the past ten years, circulating tumour cells (CTCs) have received enormous attention
as new biomarkers and the subject of basic research. Although CTCs are already used in …

A review of sorting, separation and isolation of cells and microbeads for biomedical applications: microfluidic approaches

A Dalili, E Samiei, M Hoorfar - Analyst, 2019 - pubs.rsc.org
Several biomedical analyses are performed on particular types of cells present in body
samples or using functionalized microparticles. Success in such analyses depends on the …

[HTML][HTML] High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells

M Boya, T Ozkaya-Ahmadov, BE Swain, CH Chu… - Nature …, 2022 - nature.com
Extremely rare circulating tumor cell (CTC) clusters are both increasingly appreciated as
highly metastatic precursors and virtually unexplored. Technologies are primarily designed …