Cellular responses to environmental cues involve the mobilization of GTPases, protein
kinases and phosphoprotein phosphatases. The spatial organization of these signalling …

Mitogen-activated protein kinase (MAPK) signaling pathways are highly conserved
regulators of eukaryotic cell function. These enzymes regulate many biological processes …

During its asexual blood stage, P. falciparum replicates via schizogony, wherein dozens of
daughter cells are formed within a single parent. The basal complex, a contractile ring that …

Pseudophosphatases and pseudokinases are increasingly viewed as integral elements of
signaling pathways, and there is mounting evidence that they have frequently retained the …

Tyr phosphatases are, by definition, enzymes that dephosphorylate phospho‐Tyr (pT yr)
from proteins. This activity is found in several structurally diverse protein families, including …

The 21st century is witnessing an explosive surge in our understanding of pseudoenzyme-
driven regulatory mechanisms in biology. Pseudoenzymes are proteins that have sequence …

Highlights•Pseudoenzymes are structural, but catalytically defective, homologs of
enzymes.•Examples of pseudoenzymes have been identified in all kingdoms of …

Viruses rely on the host translation machinery to synthesize their own proteins.
Consequently, they have evolved varied mechanisms to co-opt host translation for their …

Pseudoenzymes are catalytically dead counterparts of enzymes. Despite their first
description some 50 years ago, the importance and functional diversity of these 'fit-for …

Defects in signaling pathways are the root cause of many disorders. These malformations
come in a wide variety of types, and their causes are also very diverse. Some of these flaws …