T cell receptor (TCR)-peptide-major histocompatibility complex (pMHC) interactions play a
vital role in initiating immune responses against pathogens, and the specificity of TCRpMHC …

Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in
treatment over the past several decades have significantly improved the outlook for this …

Motivation Predicting the binding between T-cell receptor (TCR) and peptide presented by
human leucocyte antigen molecule is a highly challenging task and a key bottleneck in the …

Computational modelling of the interactions between T-cell receptors (TCRs) and epitopes
is of great importance for immunotherapy and antigen discovery. However, current TCR …

T cell receptor (TCR) recognition of foreign peptides presented by major histocompatibility
complex protein is a major event in triggering the adaptive immune response to pathogens …

Abstract BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …

Antigen immunogenicity and the specificity of binding of T-cell receptors to antigens are key
properties underlying effective immune responses. Here we propose diffRBM, an approach …

Reliable prediction of T cell specificity against antigenic signatures is a formidable task,
complicated by the immense diversity of T cell receptor and antigen sequence space and …

Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including
discrimination between self-and non-self-antigens, containment of immunopathology, and …

Structural docking between the adaptive immune receptors (AIRs), including T cell receptors
(TCRs) and B cell receptors (BCRs), and their cognate antigens are one of the most …