Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes

C Souilhol, J Serbanovic-Canic, M Fragiadaki… - Nature Reviews …, 2020 - nature.com
Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Vascular endothelial cells: heterogeneity and targeting approaches

JK Hennigs, C Matuszcak, M Trepel, J Körbelin - Cells, 2021 - mdpi.com
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

Consensus guidelines for the use and interpretation of angiogenesis assays

P Nowak-Sliwinska, K Alitalo, E Allen, A Anisimov… - Angiogenesis, 2018 - Springer
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Notch signaling in vascular endothelial cells, angiogenesis, and tumor progression: an update and prospective

A Akil, AK Gutiérrez-García, R Guenter… - Frontiers in cell and …, 2021 - frontiersin.org
The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

WJ Polacheck, ML Kutys, J Yang, J Eyckmans, Y Wu… - Nature, 2017 - nature.com
The vascular barrier that separates blood from tissues is actively regulated by the
endothelium and is essential for transport, inflammation, and haemostasis 1 …

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation

ME Pitulescu, I Schmidt, BD Giaimo, T Antoine… - Nature cell …, 2017 - nature.com
Endothelial sprouting and proliferation are tightly coordinated processes mediating the
formation of new blood vessels during physiological and pathological angiogenesis …

Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells

H Naito, T Iba, N Takakura - International immunology, 2020 - academic.oup.com
The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …

NOTCH1 is a mechanosensor in adult arteries

JJ Mack, TS Mosqueiro, BJ Archer, WM Jones… - Nature …, 2017 - nature.com
Endothelial cells transduce mechanical forces from blood flow into intracellular signals
required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to …

Angiogenesis in health and disease

P Carmeliet - Nature medicine, 2003 - nature.com
Blood vessels constitute the first organ in the embryo and form the largest network in our
body but, sadly, are also often deadly. When dysregulated, the formation of new blood …

Developmental and pathological angiogenesis

AS Chung, N Ferrara - Annual review of cell and developmental …, 2011 - annualreviews.org
The formation of the vascular network is an intricate and complex process that is an obligate
requirement during vertebrate development. The cardiovascular system is the first organ to …