Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

The vascular barrier that separates blood from tissues is actively regulated by the
endothelium and is essential for transport, inflammation, and haemostasis 1 …

Endothelial sprouting and proliferation are tightly coordinated processes mediating the
formation of new blood vessels during physiological and pathological angiogenesis …

Endothelial cells transduce mechanical forces from blood flow into intracellular signals
required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to …

The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …

The formation of the vascular network is an intricate and complex process that is an obligate
requirement during vertebrate development. The cardiovascular system is the first organ to …

Blood vessels constitute the first organ in the embryo and form the largest network in our
body but, sadly, are also often deadly. When dysregulated, the formation of new blood …