DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (eg,
phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl …

The axon initial segment (AIS) is located at the proximal axon and is the site of action
potential initiation. This reflects the high density of ion channels found at the AIS. Adaptive …

Objective To explore neurophysiological biomarkers of Alzheimer's disease (AD), we
investigated electroencephalography (EEG) of AD patients, and assessed lagged phase …

Monozygotic (MZ) twins share nearly all of their genetic variants and many similar
environments before and after birth. However, they can also show phenotypic discordance …

Neurons in the mature human central nervous system (CNS) perform a wide range of motor,
sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …

Different neurodegenerative disorders often show similar lesions, such as the presence of
amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited …