[HTML][HTML] In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease

N Heinen, M Kloehn, E Steinmann, S Pfaender - Viruses, 2021 - mdpi.com
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has
put scientist and pharmaceutical companies worldwide on the spot to develop novel …

[HTML][HTML] 3D lung tissue models for studies on SARS-CoV-2 pathophysiology and therapeutics

R Plebani, H Bai, L Si, J Li, C Zhang… - International Journal of …, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus
disease 2019 (COVID-19), has provoked more than six million deaths worldwide and …

[HTML][HTML] COVID-19-associated myocarditis: an evolving concern in cardiology and beyond

M Fraser, ACC Agdamag, VR Maharaj, M Mutschler… - Biology, 2022 - mdpi.com
Simple Summary Coronavirus disease-2019 (COVID-19) affects many organs in the body,
including the heart. One complication of particular concern is inflammation of the heart …

[HTML][HTML] Lung-centric inflammation of COVID-19: potential modulation by vitamin D

HMA Fakhoury, PR Kvietys, I Shakir, H Shams… - Nutrients, 2021 - mdpi.com
SARS-CoV-2 infects the respiratory tract and leads to the disease entity, COVID-19.
Accordingly, the lungs bear the greatest pathologic burden with the major cause of death …

[HTML][HTML] Experimental models to study COVID-19 effect in stem cells

RM Chugh, P Bhanja, A Norris, S Saha - Cells, 2021 - mdpi.com
The new strain of coronavirus (severe acute respiratory syndrome coronavirus type 2 (SARS-
CoV-2)) emerged in 2019 and hence is often referred to as coronavirus disease 2019 …

Modeling infectious diseases of the central nervous system with human brain organoids

TT Priyathilaka, CJ Laaker, M Herbath, Z Fabry… - Translational …, 2022 - Elsevier
Bacteria, fungi, viruses, and protozoa are known to infect and induce diseases in the human
central nervous system (CNS). Modeling the mechanisms of interaction between pathogens …

Inflammatory pathways and potential therapies for COVID-19: A mini review

AM Dabbish, N Yonis, M Salama… - European Journal …, 2021 - journals.sagepub.com
The public health crisis of the novel coronavirus disease (COVID-19) is alarming since
January 2020. COVID-19 genome (SARS-CoV-2) is related to other highly pathogenic …

[HTML][HTML] Magnitude and timing of the antiviral response determine SARS-CoV-2 replication early in infection

NR Cheemarla, TA Watkins, VT Mihaylova, B Wang… - medrxiv, 2021 - ncbi.nlm.nih.gov
The interferon response is a potent antiviral defense mechanism, but its effectiveness
depends on its timing relative to viral replication. Here, we report viral replication and host …