A keystone of antiviral immunity is CD8+ T cell recognition of viral peptides bound to MHC-I
proteins. The recognition modes of individual T cell receptors (TCRs) have been studied in …

CD8+ T cells recognizing antigenic peptides derived from conserved internal viral proteins
confer broad protection against distinct influenza viruses. As memory CD8+ T cells change …

Novel strains of influenza A viruses (IAV s) have emerged with high infectivity and/or
pathogenicity in recent years, causing worldwide concern. T cells are correlated with …

Recognition modes of individual T cell receptors (TCRs) are well studied, but factors driving
the selection of TCR repertoires from primary through persistent human virus infections are …

Overlap of TCR repertoires among individuals provides the molecular basis for public T cell
responses. By deep-sequencing the TCRβ repertoires of CD4+ CD8+ thymocytes from three …

Recurrent exposures to a pathogenic antigen remodel the CD8+ T cell compartment and
generate a functional memory repertoire that is polyclonal and complex. At the clonotype …

Chronic beryllium disease (CBD) is a granulomatous lung disease characterized by the
accumulation of beryllium (Be)-specific CD4+ T cells in bronchoalveolar lavage. These …

T-cell memory to pathogens can be envisioned as a receptor-based imprint of the
pathogenic environment on the naïve repertoire of clonotypes. Recurrent exposures to a …

The amino acids at the V–J rearrangement junction of TCR are encoded by the D region and
by N or P nucleotides. Together they comprise the NDN region, the specific pMHC selection …

The CD8 memory T cell repertoire to the influenza A derived M158–66 epitope shows a
restricted V genes and CDR3 sequences usage. The repertoire is highly polyclonal and the …