Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

The dendrites of motoneurons are not, as once thought, passive conduits for synaptic inputs.
Instead they have voltage‐dependent channels that provide the capacity to generate a very …

Epidural spinal cord stimulation (SCS) is currently regarded as a breakthrough procedure for
enabling movement after spinal cord injury (SCI), yet one of its original applications was for …

Spasticity, resulting in involuntary and sustained contractions of muscles, may evolve in
patients with stroke, cerebral palsy, multiple sclerosis, brain injury, and spinal cord injury …

Ageing is a natural process causing alterations in the neuromuscular system, which
contributes to reduced quality of life. Motor unit (MU) contributes to weakness, but the …

The excitability of spinal motoneurons is both fundamental for motor behavior and essential
in diagnosis of neural disorders. There are two mechanisms for altering this excitability. The …

Persistent inward currents (PICs) are present in many types of neurons and likely have
diverse functions. In spinal motoneurons, PICs are especially strong, primarily located in …

A well‐coordinated facilitation–inhibition control of motor neuronal persistent inward
currents (PICs) via diffuse neuromodulation and local inhibition is essential to ensure motor …

Persistent inward currents (PICs) are crucial for initiation, acceleration, and maintenance of
motoneuron firing. As PICs are highly sensitive to synaptic inhibition and facilitated by …

A fundamental challenge for the nervous system is to encode signals spanning many orders
of magnitude with neurons of limited bandwidth. To meet this challenge, perceptual systems …