This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Primary cilia are specialized microtubule‐based signaling organelles that convey
extracellular signals into a cellular response in most vertebrate cell types. The physiological …

INTRODUCTION The collective behavior of cells and insects often relies on self-organizing
processes. By releasing attractant signals, a few individuals can initiate the accumulation …

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality.
Causes are ill defined but could be through direct cardiac infection and/or inflammation …

Astrocytes respond to neurotransmitters and neuromodulators using G-protein-coupled
receptors (GPCRs) to mediate physiological responses. Despite their importance, there has …

Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

Osteoarthritis is a common progressive joint disease. As no effective medical interventions
are available, osteoarthritis often progresses to the end stage, in which only surgical options …

G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the
modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory …

Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a
versatile protein that acts as a signaling hub by modulating G protein-coupled receptor …

The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and
regeneration. Dysfunction of this cascade drives several cancers. To control expression of …