Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …

Iron is a critical component of many cellular functions including DNA replication and repair,
and it is essential for cell vitality. As an essential element, iron is critical for maintaining …

Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

Tumor suppressor p53 plays a key role in tumor suppression. In addition to tumor
suppression, p53 is also involved in many other biological and pathological processes, such …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Cells use mitophagy to remove dysfunctional or excess mitochondria, frequently in response
to imposed stresses, such as hypoxia and nutrient deprivation. Mitochondrial cargo …

Abstract p53 plays a key role in tumor suppression. The tumor suppressive function of p53
has long been attributed to its ability to induce apoptosis, cell cycle arrest, and senescence …

Mitophagy is an evolutionarily conserved cellular process which selectively eliminates
dysfunctional mitochondria by targeting them to the autophagosome for degradation …