The use of bone grafts is the standard to treat skeletal fractures, or to replace and regenerate
lost bone, as demonstrated by the large number of bone graft procedures performed …

Injectable hydrogels with biodegradability have in situ formability which in vitro/in vivo allows
an effective and homogeneous encapsulation of drugs/cells, and convenient in vivo surgical …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

Three-dimensional biomimetic scaffolds have widespread applications in biomedical tissue
engineering because of their nanoscaled architecture, eg, nanofibers and nanopores …

At present, strong requirements in orthopaedics are still to be met, both in bone and joint
substitution and in the repair and regeneration of bone defects. In this framework …

Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of
mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical …

Although several major progresses have been introduced in the field of bone regenerative
medicine during the years, current therapies, such as bone grafts, still have many limitations …

It is likely that nanofabrication will underpin many technologies in the 21st century. Synthetic
chemistry is a powerful approach to generate molecular structures that are capable of …

The repair of articular cartilage defects remains a significant challenge in orthopedic
medicine. Hydrogels, three-dimensional polymer networks swollen in water, offer a unique …

A general peptide design is presented that links the pH-dependent intramolecular folding of
β-hairpin peptides to their propensity to self-assemble, affording hydrogels rich in β-sheet …