Corneal stromal wound healing: Major regulators and therapeutic targets
S Kamil, RR Mohan - The ocular surface, 2021 - Elsevier
Corneal stromal wound healing is a complex event that occurs to restore the transparency of
an injured cornea. It involves immediate apoptosis of keratocytes followed by their activation …
an injured cornea. It involves immediate apoptosis of keratocytes followed by their activation …
Descemet's membrane development, structure, function and regeneration
RC de Oliveira, SE Wilson - Experimental eye research, 2020 - Elsevier
Basement membranes are layers of extracellular matrix which anchor the epithelium or
endothelium to connective tissues in most organs. Descemet's membrane—which is the …
endothelium to connective tissues in most organs. Descemet's membrane—which is the …
Corneal gene therapy: structural and mechanistic understanding
Cornea, a dome-shaped and transparent front part of the eye, affords 2/3rd refraction and
barrier functions. Globally, corneal diseases are the leading cause of vision impairment …
barrier functions. Globally, corneal diseases are the leading cause of vision impairment …
[HTML][HTML] Assessment of topical therapies for improving the optical clarity following stromal wounding in a novel ex vivo canine cornea model
WM Berkowski, DJ Gibson, SJ Seo… - … & Visual Science, 2018 - tvst.arvojournals.org
Purpose: To evaluate the effect of topical suberanilohydroxamic acid (SAHA) and 5-methyl-1-
phenyl-2 [1H]-pyridone (pirfenidone) on the degree of corneal haze in the stromal wounded …
phenyl-2 [1H]-pyridone (pirfenidone) on the degree of corneal haze in the stromal wounded …
The impact of biomechanics on corneal endothelium tissue engineering
MC Tsai, JT Daniels - Experimental Eye Research, 2021 - Elsevier
The integrity of innermost layer of the cornea, the corneal endothelium, is key to sustaining
corneal transparency. Therefore, disease or injury causing loss or damage to the corneal …
corneal transparency. Therefore, disease or injury causing loss or damage to the corneal …
BMP3 inhibits TGFβ2-mediated myofibroblast differentiation during wound healing of the embryonic cornea
JW Spurlin III, MR Garis, PY Lwigale - NPJ Regenerative medicine, 2022 - nature.com
Often acute damage to the cornea initiates drastic tissue remodeling, resulting in fibrotic
scarring that disrupts light transmission and precedes vision impairment. Very little is known …
scarring that disrupts light transmission and precedes vision impairment. Very little is known …
A rabbit corneal endothelial dysfunction model using endothelial-mesenchymal transformed cells
Unlike humans, rabbit corneal endothelial wounds are known to spontaneously heal. The
current study was aimed to develop a new rabbit bullous keratopathy model using corneal …
current study was aimed to develop a new rabbit bullous keratopathy model using corneal …
Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE)
Corneal wound healing, caused by frequent traumatic injury to the cornea and increasing
numbers of refractive surgeries, has become a vital clinical problem. In the cornea, wound …
numbers of refractive surgeries, has become a vital clinical problem. In the cornea, wound …
Wundheilung der Kornea–Pathophysiologie und Grundlagen
T Brockmann, M Walckling, C Brockmann… - Der …, 2021 - Springer
Die Hornhaut bildet die vordere Begrenzung des Auges und trägt durch ihre Transparenz,
Avaskularität und spezifische Krümmung wesentlich zur scharfen optischen Abbildung auf …
Avaskularität und spezifische Krümmung wesentlich zur scharfen optischen Abbildung auf …
Nidogen-2: location and expression during corneal wound healing
P Gallego-Muñoz, E Lorenzo-Martín… - Experimental Eye …, 2019 - Elsevier
Nidogen-2 is a basement membrane (BM) glycoprotein that could be a key to understanding
why defects in BM regeneration occur after severe trauma to the cornea. We monitored the …
why defects in BM regeneration occur after severe trauma to the cornea. We monitored the …