Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Nitric oxide (NO) is a gaseous reactive oxygen species (ROS) that has evolved as a
signaling hormone in many physiological processes in animals. In plants it has been …

Nitric oxide (NO) is an essential signaling molecule in biological systems. In mammals, the
diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it …

Tetrapyrrole-containing proteins are one of the most fundamental classes of enzymes in
nature and it remains an open question to give a chemical rationale for the multitude of …

Abstract Human indoleamine 2, 3-dioxygenase 1 (hIDO1) is an attractive cancer
immunotherapeutic target owing to its role in promoting tumoral immune escape. However …

Significance: Soluble guanylyl/guanylate cyclase (sGC) is the primary receptor for nitric
oxide (NO) and is central to the physiology of blood pressure regulation, wound healing …

The characteristics of heme prosthetic groups and their binding sites have been analyzed in
detail in a data set of nonhomologous heme proteins. Variations in the shape, volume, and …

Heme-nitric oxide/oxygen binding (H-NOX) domains function as sensors for the gaseous
signaling agent nitric oxide (NO) in eukaryotes and bacteria. Mammalian NO signaling is …

Heme-nitric oxide/oxygen (H-NOX) binding domains are a recently discovered family of
heme-based gas sensor proteins that are conserved across eukaryotes and bacteria. Nitric …

The diatomic molecules, O 2, NO and CO, have had a myriad of roles in biology. Due to this,
nature has developed many sensing proteins to perceive and respond to changes in the …