Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Accumulating evidence implicates that the voltage-dependent anion channel (VDAC)
functions in mitochondrion-mediated apoptosis and as a critical player in the release of …

Here, we review current evidence pointing to the function of VDAC1 in cell life and death,
and highlight these functions in relation to cancer. Found at the outer mitochondrial …

Several inhibitors of BCL2 proteins have been identified that induce apoptosis in a variety of
tumor cells, indicating their potential in cancer therapy. We investigated the specificity of six …

Lysosomes are membrane-bound organelles, which contain an arsenal of different
hydrolases, enabling them to act as the terminal degradative compartment of the …

Introduction: Enhancement of glucose metabolism and repression of oxidative
phosphorylation followed by the Warburg effect is the common hallmark of cancer cells …

Due to their central role in the regulation of apoptosis, the antiapoptotic BCL2‐proteins are
highly promising targets for the development of novel anticancer treatments. To this end …

Sanguinarine is a best-known member of a relatively small group of quaternary benzo [c]
phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae …

Betulinic acid (BetA) is a plant-derived pentacyclic triterpenoid that exerts potent anti-cancer
effects in vitro and in vivo, but is non toxic to untransformed cells. In our previous study we …