Enzymes are the most proficient catalysts, offering much more competitive processes
compared to chemical catalysts. The number of industrial applications for enzymes has …

Fragment-based drug (or lead) discovery (FBDD or FBLD) has developed in the last two
decades to become a successful key technology in the pharmaceutical industry for early …

Bioconversion of renewable lignocellulosics to produce liquid fuels and chemicals is one of
the most effective ways to solve the problem of fossil resource shortage, energy security, and …

Fluorescence resonance energy transfer (FRET) is a powerful spectroscopic method for
measuring distances in the 2–8 nm range. Often, conformational changes and molecular …

The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …

Detailed understanding of how conformational dynamics orchestrates function in allosteric
regulation of recognition and catalysis remains ambiguous. Here, we simulate CypA using …

Substrate-binding proteins (SBPs) are associated with ATP-binding cassette importers and
switch from an open to a closed conformation upon substrate binding, providing specificity …

The conformational dynamics in ABC transporters is largely elusive. The ABC importer
GlnPQ from Lactococcus lactis has different covalently linked substrate-binding domains …

Nature has evolved an optimal synthetic factory in the form of translational and
posttranslational processes by which millions of proteins with defined primary sequences …

Protein binding and function often involves conformational changes. Advanced nuclear
magnetic resonance (NMR) experiments indicate that these conformational changes can …