A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …

Affective disorders, cognitive decline, and psychosis have long been recognized as common
in Parkinson disease (PD), and other psychiatric disorders include impulse control …

Context Chronic obesity is associated with several complications, including cognitive
impairment and dementia. However, we have only piecemeal knowledge of the mechanisms …

Background: Excess weight in adulthood leads to health complications such as diabetes,
hypertension, or dyslipidemia. Recently, excess weight has also been related to brain …

Parkinson's disease varies in severity and age of onset. One source of this variability is sex.
Males are twice as likely as females to develop Parkinson's disease, and tend to have more …

White matter hyperintensities (WMHs) are commonly assumed to represent non-specific
cerebrovascular disease comorbid to neurodegenerative processes, rather than playing a …

Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD)
that poses a severe burden on the patients and caregivers, yet relatively little is known about …

ABSTRACT Background White matter hyperintensities (WMHs) have a role in cognitive
impairment in normal brain aging, while the effect on Parkinson's disease (PD) progression …

Abstract Introduction Cognitive decline in Alzheimer's disease is associated with amyloid
beta (Aβ) accumulation, neurodegeneration, and cerebral small vessel disease, but the …

Abstract Introduction White matter hyperintensities (WMHs) are common magnetic
resonance imaging (MRI) findings in the aging population in general, as well as in patients …