Exercise metabolism and adaptation in skeletal muscle
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …
been extensively researched since the landmark report by Morpurgo (1897) of “work …
Single-cell atlases: shared and tissue-specific cell types across human organs
R Elmentaite, C Domínguez Conde, L Yang… - Nature Reviews …, 2022 - nature.com
The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …
Perspectives on skeletal muscle stem cells
F Relaix, M Bencze, MJ Borok, A Der Vartanian… - Nature …, 2021 - nature.com
Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle
stem cells (MuSCs). In this review, we introduce recently developed technologies and the …
stem cells (MuSCs). In this review, we introduce recently developed technologies and the …
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells
Exercise training is critical for the prevention and treatment of obesity, but its underlying
mechanisms remain incompletely understood given the challenge of profiling …
mechanisms remain incompletely understood given the challenge of profiling …
[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration
DW McKellar, LD Walter, LT Song, M Mantri… - Communications …, 2021 - nature.com
Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …
Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution
Skeletal muscle fibers express distinct gene programs during development and maturation,
but the underlying gene regulatory networks that confer stage-specific myofiber properties …
but the underlying gene regulatory networks that confer stage-specific myofiber properties …
Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy
M Wang, Y Liu, R Sun, F Liu, J Li, L Yan, J Zhang… - Nature Genetics, 2024 - nature.com
The human placenta has a vital role in ensuring a successful pregnancy. Despite the
growing body of knowledge about its cellular compositions and functions, there has been …
growing body of knowledge about its cellular compositions and functions, there has been …
Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders
MG Huijbers, A Marx, JJ Plomp, R Le Panse… - The Lancet …, 2022 - thelancet.com
Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction
disorders. Although a plethora of immunosuppressive treatments exist, no cure is available …
disorders. Although a plethora of immunosuppressive treatments exist, no cure is available …