Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …

Purpose Endometrial cancer (EC) is often the sentinel cancer in women with Lynch
syndrome (LS). However, efforts to implement universal LS screening in EC patients have …

Background The triplet FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) plus
bevacizumab showed improved outcomes for patients with metastatic colorectal cancer …

Background In the TRIBE study, FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and
irinotecan) plus bevacizumab significantly improved progression-free survival of patients …

Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and
are well documented in families in which multiple members have had pancreatic cancer …

Purpose Lynch syndrome due to pathogenic variants in the DNA mismatch repair genes
MLH1, MSH2, and MSH6 is predominantly associated with colorectal and endometrial …

Context.—Familial adenomatous polyposis (FAP) is a rare genetic disorder with autosomal
dominant inheritance, defined by numerous adenomatous polyps, which inevitably progress …

Opinion statement Colorectal cancer (CRC) is the third leading cancer diagnosed globally
and an important cause of cancer-related mortality. Of interest, while we have witnessed a …

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women.
Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including …

Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this
conference was to develop an expert consensus-driven working framework for …