Mitochondrial dysfunction: the hidden player in the pathogenesis of atherosclerosis?

G Ciccarelli, S Conte, G Cimmino, P Maiorano… - International Journal of …, 2023 - mdpi.com
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes.
Improvements in therapy have drastically reduced the prognosis of cardiovascular disease …

Cardiovascular aging: spotlight on mitochondria

MA Ali, R Gioscia-Ryan, D Yang… - American Journal of …, 2024 - journals.physiology.org
Mitochondria are cellular organelles critical for ATP production and are particularly relevant
to cardiovascular diseases including heart failure, atherosclerosis, ischemia-reperfusion …

[HTML][HTML] Lifestyle effects on aging and CVD: a spotlight on the nutrient-sensing network

K Yang, R Hou, J Zhao, X Wang, J Wei, X Pan… - Ageing Research …, 2023 - Elsevier
Aging is widespread worldwide and a significant risk factor for cardiovascular disease
(CVD). Mechanisms underlying aging have attracted considerable attention in recent years …

Therapeutic efficacy of mitochondria-targeted esculetin in the improvement of NAFLD-NASH via modulating AMPK-SIRT1 axis

G Singuru, S Pulipaka, A Shaikh… - International …, 2023 - Elsevier
Mitochondrial dysfunction due to deregulated production of mitochondria-derived ROS is
implicated in the development and progression of non-alcoholic fatty liver disease (NAFLD) …

SIRT1-dependent PGC-1α deacetylation by SRT1720 rescues progression of atherosclerosis by enhancing mitochondrial function

JY Sung, SG Kim, YJ Kang, SY Park… - Biochimica et Biophysica …, 2024 - Elsevier
Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis via lipid-
mediated mitochondrial dysfunction and oxidative stress. However, the mechanisms of …

Pro‐inflammatory cytokines mediating senescence of vascular endothelial cells in atherosclerosis

D Shang, H Liu, Z Tu - Fundamental & Clinical Pharmacology, 2023 - Wiley Online Library
Atherosclerosis (AS) is a chronic inflammatory vascular disease, and aging is a major risk
factor. The accumulation of senescent vascular endothelial cells (VECs) often leads to …

Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism …

Q Mao, M Deng, J Zhao, D Zhou, W Tong, S Xu… - Mechanisms of Ageing …, 2023 - Elsevier
Objective We aimed to evaluate the prognostic performance of circulating Klotho in coronary
atherosclerotic disease (CAD), and to further explore the effect of Klotho on stress-mediated …

[HTML][HTML] The regulatory role and mechanism of energy metabolism in vascular diseases

T Sun, W Yuan, Y Wei, D Liao, Q Tuo - Frontiers in Bioscience …, 2024 - imrpress.com
Vascular diseases are amongst the most serious diseases affecting human life and health
globally. Energy metabolism plays a crucial role in multiple vascular diseases, and the …

[HTML][HTML] m 6A methylation in cellular senescence of age-associated diseases: m 6A methylation in cellular senescence of age-associated diseases

P Gao, F Yao, J Pang, K Yin, X Zhu - Acta Biochimica et Biophysica …, 2023 - ncbi.nlm.nih.gov
Cellular senescence is a state of irreversible cellular growth arrest that occurs in response to
various stresses. In addition to exiting the cell cycle, senescent cells undergo many …

Dihydrokaempferol attenuates LPS-induced inflammation and apoptosis in WI-38 cells

Q Wang, L Zhang, P Pang - Allergologia et Immunopathologia, 2023 - all-imm.com
Background: Globally, pneumonia has been associated as a primary cause of mortality in
children aged less than 5 years. Dihydrokaempferol (DHK) has been proposed for being …