Preeclampsia is one of the “great obstetrical syndromes” in which multiple and sometimes
overlapping pathologic processes activate a common pathway consisting of endothelial cell …

The placenta is a central structure in pregnancy and has pleiotropic functions. This organ
grows incredibly rapidly during this period, acting as a mastermind behind different fetal and …

Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …

Motivation Ageing is a biological and psychosocial process related to diseases and
mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues …

Aberrant placental ageing is implicated in a high percentage of birth complications, stillbirths
and neonatal deaths. Understanding how this complex organ is established and maintained …

Preeclampsia (PE), the leading cause of maternal and fetal morbidity and mortality, is
associated with poor fetal growth, intrauterine growth restriction (IUGR) and low birth weight …

The human pan-tissue epigenetic clock is widely used for estimating age across the entire
lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental …

Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines,
growth factors, and remodeling proteins (senescence-associated secretory phenotype; …

It is well-known, but frequently overlooked, that low-and high-throughput molecular data may
contain batch effects, ie, systematic technical variation. Confounding of experimental …

Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-
traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity …