Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

Break-induced replication (BIR) is a pathway that repairs one-ended double-strand breaks
(DSBs). For decades, yeast model systems offered the only opportunities to study eukaryotic …

INTRODUCTION Thalidomide, lenalidomide, and pomalidomide are clinically approved
therapies for the treatment of multiple myeloma and other hematologic malignancies. These …

Repair of damaged DNA is essential for maintaining genome integrity and for preventing
genome-instability-associated diseases, such as cancer. By combining proximity labeling …

Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that
simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination …

BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA
metabolism, including homologous recombination and mediating the replication stress …

Activation of a telomere maintenance mechanism (TMM) is permissive for replicative
immortality and a hallmark of human cancer. While most cancers rely on reactivation of …

To escape replicative senescence, cancer cells have to overcome telomere attrition during
DNA replication. Most of cancers rely on telomerase to extend and maintain telomeres, but 4 …

How chromatin shapes pathways that promote genome–epigenome integrity in response to
DNA damage is an issue of crucial importance. We report that human bromodomain (BRD) …

Telomeres shorten during each cellular division, with cumulative attrition resulting in
telomeric damage and replicative senescence. Bypass of replicative senescence …