Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

[HTML][HTML] Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms

JR Petrie, TJ Guzik, RM Touyz - Canadian Journal of Cardiology, 2018 - Elsevier
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as
frequent in patients with diabetes compared with those who do not have diabetes. Moreover …

Cytokines and abnormal glucose and lipid metabolism

J Shi, J Fan, Q Su, Z Yang - Frontiers in endocrinology, 2019 - frontiersin.org
Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …

[HTML][HTML] Mechanisms of diabetes-induced liver damage: the role of oxidative stress and inflammation

J Mohamed, AHN Nafizah, AH Zariyantey… - Sultan qaboos …, 2016 - ncbi.nlm.nih.gov
Diabetes mellitus is a non-communicable disease that occurs in both developed and
developing countries. This metabolic disease affects all systems in the body, including the …

Inflammation and neuro-immune dysregulations in autism spectrum disorders

D Siniscalco, S Schultz, AL Brigida, N Antonucci - Pharmaceuticals, 2018 - mdpi.com
Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social
communication and interaction and restricted-repetitive patterns of behavior, interests, or …

NLRP3 inflammasome at the interface of inflammation, endothelial dysfunction, and type 2 diabetes

IM Gora, A Ciechanowska, P Ladyzynski - Cells, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation

S Muralidharan, P Mandrekar - Journal of leukocyte biology, 2013 - academic.oup.com
Extensive research in the past decade has identified innate immune recognition receptors
and intracellular signaling pathways that culminate in inflammatory responses. Besides its …

Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease

N Esser, N Paquot, AJ Scheen - Expert opinion on investigational …, 2015 - Taylor & Francis
Introduction: There is a growing body of evidence to suggest that chronic silent inflammation
is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and …

Frailty, sarcopenia and diabetes

JE Morley, TK Malmstrom, L Rodriguez-Mañas… - Journal of the American …, 2014 - jamda.com
Conclusion Both frailty and sarcopenia are common occurrences in persons older than 55
years with diabetes (Figure 3). They are highly correlated with poor outcomes and are …

The role of interleukin-1β in type 2 diabetes mellitus: A systematic review and meta-analysis

H Alfadul, S Sabico, NM Al-Daghri - Frontiers in Endocrinology, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is a multifactorial non-communicable disease that is
characterized by insulin resistance and chronic sub-clinical inflammation. Among the …