The discovery of a diverse and unique subset of ion channels in T lymphocytes has led to a
rapidly growing body of knowledge about their functional roles in the immune system. Potent …

▪ Abstract Potassium channels are multi-subunit complexes, often composed of several
polytopic membrane proteins and cytosolic proteins. The formation of these oligomeric …

The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated K+ channels
encodes molecular determinants for subfamily-specific assembly of α-subunits into …

We have cloned from murine erythroleukemia (MEL) cells, thymus, and stomach the cDNA
encoding the Ca 2+-gated K+(K Ca) channel, mIK1, the mouse homolog of hIK1 (Ishii, TM …

Transient receptor potential (TRP) proteins form cation-conducting ion channels with
currently 28 known genes encoding TRP channel monomers in mammals. These monomers …

All plant channels identified so far show high conservation throughout the polypeptide
sequence except in the ankyrin domain which is present only in those closely related to …

Calmodulin (CaM) regulates gating of several types of ion channels but has not been
implicated in channel assembly or trafficking. For the SK4/IK1 K+ channel, CaM bound to the …

Genes with sequences reminiscent of neuronal K+ channels have recently been identified in
prokaryotes. These putative K+ channels appear to be integral membrane proteins, with …

To probe the molecular identity of transient outward (A-type) potassium currents, we
expressed a truncated version of Kv4. 2 in heart cells and neurons. The rat Kv4. 2-coding …

Electrically silent voltage-gated potassium (KvS) α-subunits do not form homotetramers but
heterotetramerize with Kv2 subunits, generating functional Kv2/KvS channel complexes in …