Ion channels in the immune system as targets for immunosuppression
MD Cahalan, KG Chandy - Current Opinion in Biotechnology, 1997 - Elsevier
The discovery of a diverse and unique subset of ion channels in T lymphocytes has led to a
rapidly growing body of knowledge about their functional roles in the immune system. Potent …
rapidly growing body of knowledge about their functional roles in the immune system. Potent …
Potassium channel ontogeny
C Deutsch - Annual review of physiology, 2002 - annualreviews.org
▪ Abstract Potassium channels are multi-subunit complexes, often composed of several
polytopic membrane proteins and cytosolic proteins. The formation of these oligomeric …
polytopic membrane proteins and cytosolic proteins. The formation of these oligomeric …
Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels
KA Bixby, MH Nanao, NV Shen, A Kreusch… - Nature structural …, 1999 - nature.com
The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated K+ channels
encodes molecular determinants for subfamily-specific assembly of α-subunits into …
encodes molecular determinants for subfamily-specific assembly of α-subunits into …
[HTML][HTML] cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1: roles in regulatory volume decrease and erythroid differentiation
DH Vandorpe, BE Shmukler, L Jiang, B Lim… - Journal of Biological …, 1998 - ASBMB
We have cloned from murine erythroleukemia (MEL) cells, thymus, and stomach the cDNA
encoding the Ca 2+-gated K+(K Ca) channel, mIK1, the mouse homolog of hIK1 (Ishii, TM …
encoding the Ca 2+-gated K+(K Ca) channel, mIK1, the mouse homolog of hIK1 (Ishii, TM …
[HTML][HTML] Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat
I Erler, D Hirnet, U Wissenbach, V Flockerzi… - Journal of Biological …, 2004 - ASBMB
Transient receptor potential (TRP) proteins form cation-conducting ion channels with
currently 28 known genes encoding TRP channel monomers in mammals. These monomers …
currently 28 known genes encoding TRP channel monomers in mammals. These monomers …
[HTML][HTML] Tetramerization of the AKT1 plant potassium channel involves its C‐terminal cytoplasmic domain
P Daram, S Urbach, F Gaymard, H Sentenac… - The EMBO …, 1997 - embopress.org
All plant channels identified so far show high conservation throughout the polypeptide
sequence except in the ankyrin domain which is present only in those closely related to …
sequence except in the ankyrin domain which is present only in those closely related to …
[HTML][HTML] Calmodulin regulates assembly and trafficking of SK4/IK1 Ca2+-activated K+ channels
Calmodulin (CaM) regulates gating of several types of ion channels but has not been
implicated in channel assembly or trafficking. For the SK4/IK1 K+ channel, CaM bound to the …
implicated in channel assembly or trafficking. For the SK4/IK1 K+ channel, CaM bound to the …
Tetrameric Stoichiometry of a Prokaryotic K+ Channel
L Heginbotham, E Odessey, C Miller - Biochemistry, 1997 - ACS Publications
Genes with sequences reminiscent of neuronal K+ channels have recently been identified in
prokaryotes. These putative K+ channels appear to be integral membrane proteins, with …
prokaryotes. These putative K+ channels appear to be integral membrane proteins, with …
[HTML][HTML] Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant-negative Kv4. 2 constructs
DC Johns, HB Nuss, E Marban - Journal of Biological Chemistry, 1997 - ASBMB
To probe the molecular identity of transient outward (A-type) potassium currents, we
expressed a truncated version of Kv4. 2 in heart cells and neurons. The rat Kv4. 2-coding …
expressed a truncated version of Kv4. 2 in heart cells and neurons. The rat Kv4. 2-coding …
Electrically silent Kv subunits: their molecular and functional characteristics
E Bocksteins, DJ Snyders - Physiology, 2012 - journals.physiology.org
Electrically silent voltage-gated potassium (KvS) α-subunits do not form homotetramers but
heterotetramerize with Kv2 subunits, generating functional Kv2/KvS channel complexes in …
heterotetramerize with Kv2 subunits, generating functional Kv2/KvS channel complexes in …