[HTML][HTML] Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential

W Zhang, C Xu, J Sun, HM Shen, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

[HTML][HTML] Involvement of p38 MAPK in synaptic function and dysfunction

C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …

[HTML][HTML] Vaccine adjuvants to engage the cross-presentation pathway

W Lee, M Suresh - Frontiers in immunology, 2022 - frontiersin.org
Adjuvants are indispensable components of vaccines for stimulating optimal immune
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …

[HTML][HTML] Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy

C Yang, C Su, A Iyaswamy, SK Krishnamoorthi… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the accumulation of protein aggregates
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …

[HTML][HTML] TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress

K Zhou, Z Zheng, Y Li, W Han, J Zhang, Y Mao… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Background and Aim: Increasing evidence suggests that spinal cord injury (SCI)-
induced defects in autophagic flux may contribute to an impaired ability for neurological …

Autophagy in health and disease: From molecular mechanisms to therapeutic target

G Lu, Y Wang, Y Shi, Z Zhang, C Huang, W He… - MedComm, 2022 - Wiley Online Library
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

[HTML][HTML] Mesenchymal stem cells exosomal let-7a-5p improve autophagic flux and alleviate liver injury in acute-on-chronic liver failure by promoting nuclear …

D Lin, H Chen, J Xiong, J Zhang, Z Hu, J Gao… - Cell Death & …, 2022 - nature.com
Acute-on-chronic liver failure is a distinct clinical syndrome characterized by a dysregulated
immune response and extensive hepatocyte death without satisfactory therapies. As a …

Cyclic helix B peptide promotes random‐pattern skin flap survival via TFE3‐mediated enhancement of autophagy and reduction of ROS levels

J Lou, H Zhang, J Qi, Y Xu, X Wang… - British journal of …, 2022 - Wiley Online Library
Background and Purpose Necrosis of random‐pattern skin flaps limits their clinical
application. Helix B surface peptide (HBSP) protects tissues from ischaemia–reperfusion …

GDF‐11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3‐Mediated Autophagy Augmentation

Y Xu, X Hu, F Li, H Zhang, J Lou… - Oxidative Medicine …, 2021 - Wiley Online Library
Spinal cord injury (SCI) refers to a major worldwide cause of accidental death and disability.
However, the complexity of the pathophysiological mechanism can result in less‐effective …

[HTML][HTML] Klotho an autophagy stimulator as a potential therapeutic target for Alzheimer's disease: A review

TY Fung, A Iyaswamy, SG Sreenivasmurthy… - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is an age-associated neurodegenerative disease; it is the most
common cause of senile dementia. Klotho, a single-pass transmembrane protein primarily …