In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of
the myeloid lineage. Transcription factors have been shown to be key determinants in the …

CCAAT/enhancer binding protein α (C/EBPα) dimerizes via its leucine zipper (LZ) domain to
bind DNA via its basic region and activate transcription via N-terminal trans-activation …

The CCATT/enhancer binding protein alpha, C/EBPα, is a key transcription factor involved in
late differentiation events of several cell types. Besides acting as a classical transcription …

The C/EBPα transcription factor regulates hepatic nitrogen, glucose, lipid and iron
metabolism. However, how it is able to independently control these processes is not known …

In the course of the last decades, metabolism research has demonstrated that adipose
tissue is not an inactive tissue. Rather, adipocytes are key actors of whole body energy …

Despite significant advancements in our understanding of cancer development, the
molecular mechanisms that underlie the formation of liver cancer remain largely unknown …

Steroid hormones are key gene regulators in breast cancer cells. While estrogens stimulate
cell proliferation, progestins activate a single cell cycle followed by proliferation arrest. Here …

Disturbances of circadian rhythms and mammalian clock genes have been implicated in the
etiologies of many chronic illnesses, including cancer. We show that transcription factor …

The copper (II), nickel (II) and zinc (II) binding ability of the multi-histidine peptide N-acetyl-
His-Pro-His-His-NH2 has been studied by combined pH-potentiometry and visible, CD and …

The transcription factor CCAAT/enhancer binding protein (C/EBP) α is a myeloid-specific
transcription factor which is required for normal myeloid differentiation. C/EBPα is encoded …