Abs are versatile molecules with the potential to achieve exceptional binding to target Ags,
while also possessing biophysical properties suitable for therapeutic drug development …

Mutations in protein active sites can dramatically improve function. The active site, however,
is densely packed and extremely sensitive to mutations. Therefore, some mutations may …

In the past 40 years, therapeutic antibody discovery and development have advanced
considerably, with machine learning (ML) offering a promising way to speed up the process …

Although in silico folding based on coevolving residue constraints in the deep‐learning era
has transformed protein structure prediction, the contributions of coevolving residues to …

Reactive oxygen species (ROS) are produced during cellular metabolism and in response to
environmental stress. While low levels of ROS play essential physiological roles, excess …

Plant genomics and crop breeding are at the intersection of biotechnology and information
technology. Driven by a combination of high-throughput sequencing, molecular biology and …

Proteins are essential macromolecules that play crucial roles in nearly every type of
biological function. Most of the protein functions are determined by their position topologies …

Medium optimization and development for selective bacterial cultures are essential for
isolating and functionalizing individual bacteria in microbial communities; nevertheless, it …

Proteins are the fundamental macromolecules that play diverse and crucial roles in all living
matter and have tremendous implications in healthcare, manufacturing, and biotechnology …

Broadly neutralizing antibodies (bnAbs) typically evolve cross-reactivity breadth through
acquiring somatic hypermutations. While evolution of breadth requires improvement of …