Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of
congenital diseases including microcephaly in newborn and Guillain-Barré syndrome (GBS) …

The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well
documented, but other aspects of the pandemic, such as attack rates and risk factors, are …

Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in
individuals who develop high titers of anti-ZIKV antibodies, we screened cohorts in Brazil …

Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different
dengue virus (DENV) serotypes (1–4) and manifests in the form of symptoms ranging from …

Background The co-circulation of flaviviruses in tropical regions has led to the hypothesis
that immunity generated by a previous dengue infection could promote severe disease …

Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share
cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of …

The flaviviruses are small single-stranded RNA viruses that are typically transmitted by
mosquito or tick vectors. These “arboviruses” are found around the world and account for a …

Background Since 2015, the arthropod-borne viruses (arboviruses) Zika and chikungunya
have spread across the Americas causing outbreaks, accompanied by increases in immune …

Antibody-dependent enhancement (ADE) is a phenomenon in which preexisting poorly
neutralizing antibodies leads to enhanced infection. It is a serious concern with mosquito …