Coumarin: A natural, privileged and versatile scaffold for bioactive compounds

A Stefanachi, F Leonetti, L Pisani, M Catto, A Carotti - Molecules, 2018 - mdpi.com
Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …

Proteomics, networks and connectivity indices

H González‐Díaz, Y González‐Díaz, L Santana… - …, 2008 - Wiley Online Library
Describing the connectivity of chemical and/or biological systems using networks is a
straight gate for the introduction of mathematical tools in proteomics. Networks, in some …

Comparative QSARs for antimalarial endochins: Importance of descriptor-thinning and noise reduction prior to feature selection

PK Ojha, K Roy - Chemometrics and Intelligent Laboratory Systems, 2011 - Elsevier
The emergence of multidrug resistance of the currently available antimalarial drugs has led
to the need of the discovery and development of new antimalarial compounds. In the present …

Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors

MJ Matos, C Teran, Y Perez-Castillo… - Journal of medicinal …, 2011 - ACS Publications
New series of 6-substituted-3-arylcoumarins displaying several alkyl, hydroxyl, halogen, and
alkoxy groups in the two benzene rings have been designed, synthesized, and evaluated in …

New frontiers in the transition-metal-free synthesis of heterocycles from alkynoates: an overview and current status

I Khan, S Zaib, A Ibrar - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
Heterocycles are among the well-established classes of compounds, constituting a wide
range of organic molecules. These structural motifs not only have a dominant presence in a …

Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins

F Chimenti, D Secci, A Bolasco… - Journal of medicinal …, 2009 - ACS Publications
A large series of 3-carboxamido-7-substituted coumarins have been synthesized and tested
in vitro for their human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitory …

Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents

KV Sashidhara, A Kumar, M Chatterjee, KB Rao… - Bioorganic & medicinal …, 2011 - Elsevier
A series of 3-phenylcoumarins were synthesized and screened for potential antidepressant
activity by tail suspension test (TST) in mice. Three compounds (6, 7 and 13) exhibited …

General theory for multiple input-output perturbations in complex molecular systems. 1. Linear QSPR electronegativity models in physical, organic, and medicinal …

H Gonzalez-Diaz, S Arrasate… - Current topics in …, 2013 - ingentaconnect.com
In general perturbation methods starts with a known exact solution of a problem and add
“small” variation terms in order to approach to a solution for a related problem without known …

Structure-based design and classifications of small molecules regulating the circadian rhythm period

S Gul, F Rahim, S Isin, F Yilmaz, N Ozturk, M Turkay… - Scientific reports, 2021 - nature.com
Circadian rhythm is an important mechanism that controls behavior and biochemical events
based on 24 h rhythmicity. Ample evidence indicates disturbance of this mechanism is …

Zinc Oxide Nanoparticles as Efficient Heterogeneous Catalyst for Synthesis of Bio‐active Heterocyclic Compounds

G Kumar, V Tomar, P Kumar, M Nemiwal - ChemistrySelect, 2023 - Wiley Online Library
Among the most effective recoverable catalytic systems, metal‐oxide nanoparticles (NPs)
are well known for their extensive uses in a broad range of industries, pharmaceuticals, and …