G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

Cannabinoids comprise a broad group of psychoactive substances that activate
endogenous cannabinoid (EC) receptors (ie, CB1R and CB2R), altering neurotransmitter …

Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol
(THC); however, up to 120 types of phytocannabinoids are present in hemp. Hemp leaves …

The mammalian brain stores and distinguishes among episodic memories, ie memories
formed during the personal experience, through a mechanism of pattern separation …

The microdomain that orchestrates action potential initiation in neurons is the axon initial
segment (AIS). It has long been considered to be a rather homogeneous domain at the very …

With the increase of life expectancy, neurodegenerative disorders are becoming not only a
health but also a social burden worldwide. However, due to the multitude of …

Background Maintenance of weight is essential for sustenance, well-being and to endorse
prolonged life. The prevalence of obesity is increasing at an alarming rate globally, due to …

Brain channelopathies are a group of neurological disorders that result from genetic
mutations affecting ion channels in the brain. Ion channels are specialized proteins that play …

Endocannabinoids (eCB) modulate growth cone dynamics and axonal pathfinding through
the stimulation of cannabinoid type-1 receptors (CB1R), the function of which depends on …

The axon initial segment (AIS) is essential for action potential generation. Recently, the AIS
was identified as a site of neuronal plasticity. A subpopulation of AIS in cortical principal …