When embryological development of the internal and/or external genitalia is disrupted, the
patient presents with a disorder of sex development (DSD) in the neonatal period or …

The exstrophy‐epispadias complex is a rare spectrum of malformations affecting the
genitourinary system, anterior abdominal wall, and pelvis. Historically, surgical outcomes …

Congenital anomalies of the kidney and urinary tract (CAKUTs) represent the leading cause
of chronic kidney disease and end-stage kidney disease in children. Increasing evidence …

The bladder exstrophy-epispadias complex (BEEC) represents the severe end of the uro-
rectal malformation spectrum, and is thought to result from aberrant embryonic …

The mammalian ureter contains a water-tight epithelium surrounded by smooth muscle. Key
molecules have been defined which regulate ureteric bud initiation and drive the …

Previously genome-wide association methods in patients with classic bladder exstrophy
(CBE) found association with ISL1, a master control gene expressed in pericloacal …

Congenital anomalies of the kidney and urinary tract (CAKUT) represent a broad range of
diseases with differing mechanisms, clinical presentations, and prognoses. With an …

Bladder exstrophy-epispadias complex (BEEC), the severe end of the urorectal
malformation spectrum, has a profound impact on continence as well as sexual and renal …

The Bladder-Exstrophy-Epispadias Complex (BEEC) represents the severe end of the
urorectal malformation spectrum, and has a profound impact on continence, and on sexual …

The bladder exstrophy–epispadias complex (BEEC) is an abdominal midline malformation
comprising a spectrum of congenital genitourinary abnormalities of the abdominal wall …