The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Cancer cells disseminate and seed in distant organs, where they can remain dormant for
many years before forming clinically detectable metastases. Here we studied how …

Invadopodia are a subset of invadosomes that are implicated in the integration of signals
from the tumor microenvironment to support tumor cell invasion and dissemination. Recent …

Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a
poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the …

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

The activation and accumulation of lung fibroblasts resulting in aberrant deposition of
extracellular matrix components, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis …

Unraveling the mechanisms that govern the formation and function of invadopodia is
essential towards the prevention of cancer spread. Here, we characterize the ultrastructural …

Cancer cells' ability to migrate through constricting pores in the tissue matrix is limited by
nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating …