The micromechanics of lung alveoli: structure and function of surfactant and tissue components

L Knudsen, M Ochs - Histochemistry and cell biology, 2018 - Springer
The mammalian lung´ s structural design is optimized to serve its main function: gas
exchange. It takes place in the alveolar region (parenchyma) where air and blood are …

[HTML][HTML] Bronchopulmonary dysplasia: a review of pathogenesis and pathophysiology

RK Thekkeveedu, MC Guaman, B Shivanna - Respiratory medicine, 2017 - Elsevier
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of primarily premature infants
that results from an imbalance between lung injury and repair in the developing lung. BPD is …

Effect of titrating positive end-expiratory pressure (PEEP) with an esophageal pressure–guided strategy vs an empirical high PEEP-FIO2 strategy on death and days …

JR Beitler, T Sarge, VM Banner-Goodspeed, MN Gong… - Jama, 2019 - jamanetwork.com
Importance Adjusting positive end-expiratory pressure (PEEP) to offset pleural pressure
might attenuate lung injury and improve patient outcomes in acute respiratory distress …

Ventilator-induced lung injury

AS Slutsky, VM Ranieri - New England Journal of Medicine, 2013 - Mass Medical Soc
Ventilator-Induced Lung Injury | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Ventilator-induced lung injury

JR Beitler, A Malhotra… - Clinics in chest …, 2016 - chestmed.theclinics.com
As with most medical and pharmacologic interventions, mechanical ventilation must be
titrated within a therapeutic window, providing the required lifesustaining support while …

Reconstituting organ-level lung functions on a chip

D Huh, BD Matthews, A Mammoto, M Montoya-Zavala… - Science, 2010 - science.org
Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-
capillary interface of the human lung. This bioinspired microdevice reproduces complex …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

Multiphase monolith reactors: chemical reaction engineering of segmented flow in microchannels

MT Kreutzer, F Kapteijn, JA Moulijn… - Chemical Engineering …, 2005 - Elsevier
The use of segmented flow in capillaries, also known as Taylor flow, for reaction engineering
purposes has soared in recent years. On the one hand, Taylor flow has been used in …

Methods of delivering mechanical stimuli to organ-on-a-chip

K Kaarj, JY Yoon - Micromachines, 2019 - mdpi.com
Recent advances in integrating microengineering and tissue engineering have enabled the
creation of promising microengineered physiological models, known as organ-on-a-chip …

[HTML][HTML] Current perspectives in pulmonary surfactant—inhibition, enhancement and evaluation

YY Zuo, RAW Veldhuizen, AW Neumann… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Pulmonary surfactant (PS) is a complicated mixture of approximately 90% lipids and 10%
proteins. It plays an important role in maintaining normal respiratory mechanics by reducing …