Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …
Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
An overview of the cardiorenal protective mechanisms of SGLT2 inhibitors
T Salvatore, R Galiero, A Caturano, L Rinaldi… - International Journal of …, 2022 - mdpi.com
Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …
Neuroprotective effect of SGLT2 inhibitors
A Pawlos, M Broncel, E Woźniak, P Gorzelak-Pabiś - Molecules, 2021 - mdpi.com
Patients with diabetes are at higher risk of cardiovascular diseases and cognitive
impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin …
impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin …
Anti-inflammatory role of SGLT2 inhibitors as part of their anti-atherosclerotic activity: data from basic science and clinical trials
L Scisciola, V Cataldo, F Taktaz… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis is a progressive inflammatory disease leading to mortality and morbidity in
the civilized world. Atherosclerosis manifests as an accumulation of plaques in the intimal …
the civilized world. Atherosclerosis manifests as an accumulation of plaques in the intimal …
Effects of sodium-glucose co-transporter 2 inhibitors on vascular cell function and arterial remodeling
Cardiovascular disease is the leading cause of morbidity and mortality in diabetes. Recent
clinical studies indicate that sodium-glucose co-transporter 2 (SGLT2) inhibitors improve …
clinical studies indicate that sodium-glucose co-transporter 2 (SGLT2) inhibitors improve …
Dapagliflozin exerts anti-inflammatory effects via inhibition of LPS-induced TLR-4 overexpression and NF-κB activation in human endothelial cells and differentiated …
E Abdollahi, F Keyhanfar, AA Delbandi, R Falak… - European Journal of …, 2022 - Elsevier
Evidence has demonstrated that a new class of anti-diabetic drugs, sodium-glucose co-
transporter 2 (SGLT2) inhibitors, could exert beneficial effects on atherosclerotic …
transporter 2 (SGLT2) inhibitors, could exert beneficial effects on atherosclerotic …
Metformin, macrophage dysfunction and atherosclerosis
Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …
treat many diseases. More and more evidence shows that metformin can regulate the …
The impact of SGLT2 inhibitors on inflammation: A systematic review and meta-analysis of studies in rodents
Background Inhibition of sodium-glucose cotransporter-2 (SGLT2) has received remarkable
attention due to the beneficial effects observed in diabetes mellitus, heart failure, and kidney …
attention due to the beneficial effects observed in diabetes mellitus, heart failure, and kidney …
[HTML][HTML] Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function
As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates
glucose levels and positively affects cardiovascular function in patients with diabetes and …
glucose levels and positively affects cardiovascular function in patients with diabetes and …