Integrins are cell surface transmembrane receptors that recognize and bind to extracellular
matrix proteins and counter receptors. Binding of activated integrins to their ligands induces …

▪ Abstract Phagocytosis and phagolysosome biogenesis represent fundamental biological
processes essential for proper tissue homeostasis, development, elimination of invading …

Signal transduction down the Ras/MAPK pathway, including that critical to T cell activation,
proliferation, and differentiation, has been generally considered to occur at the plasma …

During development of multicellular organisms, cells respond to extracellular cues through
nonlinear signal transduction cascades whose principal components have been identified …

Organometallic half-sandwich complexes [M (p-cymene)(azo/imino-pyridine) X]+ where M=
RuII or OsII and X Cl or I, exhibit potent antiproliferative activity toward a range of cancer …

Four mononuclear terpyridine complexes [Cu (H-La) Cl2]· CH3OH (1),[Cu (H-La) Cl] ClO4
(2),[Cu (H-Lb) Cl2]· CH3OH (3), and [Cu (H-Lb)(CH3OH)(DMSO)](ClO4) 2 (4) were prepared …

The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as
FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these …

Tissue remodeling is critical during development and wound healing. It also characterizes a
number of pathologic conditions, including chronic inflammation, fibrosis and cancer. It is …

The Met receptor tyrosine kinase (RTK) regulates epithelial remodeling, dispersal, and
invasion and is deregulated in many human cancers. It is now accepted that impaired down …

The extracellular signal-regulated kinase (ERK) cascade regulates proliferation,
differentiation, and survival in multicellular organisms. Scaffold proteins regulate intracellular …